Wan, L.#, Zhang, C.#, Liu, Y.#, Zhang, J., He, L., Zhang, Y., ...Chen, G.*, Guo, P.*, & Han, D.* (2025). Small CAG Repeat RNA Forms a Duplex Structure with Sticky Ends That Promote RNA Condensation. Journal of the American Chemical Society, 147(4), 3813-3822.

Yang, J., Xu, X., Yang, L., Tian, Y., Wang, J.*, & Han, D.* (2025). Dynamic Genomic Imaging and Tracking in Living Cells by a DNA Origami‐Based CRISPR‒dCas9 System. Small  Methods, 9(6), 2401559.

Zhang, L.#, Yang, H.#, Yan, Y., Zhao, H., Han, D*., & Su, X. (2025). A Multi‐Input Molecular Classifier Based on Digital DNA Strand Displacement for Disease Diagnostics. Advanced  Materials, 37(10), e2413198.

Wu, J.#, Gao, Q.#, Xia, Q.#, Wang, Y., Zheng, Z., He, A., ...Miao, Y.*, & Han, D.* (2025). Highly Specific Cytokine Receptor‐Targeting Chimeras for Targeted Membrane Protein Degradation and Sensitization of Osimertinib in EGFR‐Mutated Non‐Small‐Cell Lung Cancer. Advanced  Materials, 37(32), 2504050.

Hou, J., Guo, P., Wang, J., Han, D.*, & Tan, W. (2024). Artificial dynamic structure ensemble-guided rational design of a universal RNA aptamer–based sensing tag. Proceedings of the National Academy of Sciences, 121(52), e2414793121.

Huang, Z., Du, Z., Li, J., Han, D., He, J., Yang, Y., ... & Tan, W. (2024). Aptamer-Based Activatable Tyramide Signal Amplification for Low-Background Detection of SARS-CoV-2 Nucleocapsid Protein. Analytical Chemistry, 97(1), 328-336.

Peng, X., Teng, X., Ma, Q., & Han, D.* (2024). Serum circulating mRNA panel for the early detection of gastric cancer: a potential biomarker test. ChemMedChem, 19(24), e202400523.

Lai, Z., Jin, D., Tian, Y., Chen, X., Han, D., Chen, H., ... & Yang, Y. (2024). Enhanced Sensitivity of Cell Identification in Complex Environments Using Chirally Inverted L‐DNA‐Based Logic Devices. Advanced Science, 11(45), 2410642.

Peng, X., Ma, Q., & Han, D.* (2024). Recent advances in exploring new blood-based biomarkers for the early diagnosis of gastric cancer. Science China Chemistry, 68, 35–45.

Diao, N., Hou, J., Peng, X., Wang, Y., He, A., Gao, H., ... Wang, J.*​, & Han, D.* (2024). Multiplexed and Quantitative Imaging of Live‐Cell Membrane Proteins by a Precise and Controllable DNA‐Encoded Amplification Reaction. Angewandte Chemie International Edition, 63(40), e202406330.

Su, X., Zheng, Q., Xiu, X., Zhao, Q., Wang, Y., Han, D.*, & Song, P. (2024). Challenges and prospects in utilizing technologies for gene fusion analysis in cancer diagnostics. Med-X, 2(1), 14.

Song, M., Wang, J., Hou, J., Fu, T., Feng, Y., Lv, W., ..., Ruizi Peng.*​, Han, D.* & Tan, W. (2024). Multiplexed In Situ Imaging of Site-Specific m6A Methylation with Proximity Hybridization Followed by Primer Exchange Amplification (m6A-PHPEA). ACS Nano, 18(40), 27537-27546.

He, A., Xia, F., Han, D., Yang, Q., & Tan, W. (2024). Self-assembled amphiphilic NIR-II emissive nano-micelles for imaging-guided photothermal therapy of colorectal cancer. Science China Chemistry, 67(8), 2767-2774.

Li, C., Wang, D., Gao, H., Fu, T., He, L.*​, Han, D.*, & Tan, W. (2024). Leveraging DNA‐Encoded Cell‐Mimics for Environment‐Adaptive Transmembrane Channel Release‐Induced Cell Death. Angewandte Chemie International Edition, 63(30), e202406186.

He, A., Wan, L., Zhang, Y., Yan, Z., Guo, P.*, Han, D.*, & Tan, W. (2024). Structure-based investigation of a DNA aptamer targeting PTK7 reveals an intricate 3D fold guiding functional optimization. Proceedings of the National Academy of Sciences, 121(29), e2404060121.

Liu, J., & Han, D.* (2024). General-purpose DNA computation. Science China Chemistry, 67(7), 2134-2135.

Yang, J., & Han, D.* (2024). Building DNA Computing System for Smart Biosensing and Clinical Diagnosis. DNA Nanotechnology for Cell Research: From Bioanalysis to Biomedicine, 211-231.

Yang, L., Tang, Q., Zhang, M., Tian, Y., Chen, X., Xu, R., ... Zhang, C.*, & Han, D.* (2024). A spatially localized DNA linear classifier for cancer diagnosis. Nature Communications, 15(1), 4583.

Zhang, M., Yancey, C., Zhang, C., Wang, J., Ma, Q., Yang, L., ..., Han, D.* & Tan, W. (2024). A DNA circuit that records molecular events. Science Advances, 10(14), eadn3329.

Wang, Y., Wang, J., Yan, Z., Hou, J., Wan, L., Yang, Y., ... Guo, P.*, & Han, D.* (2024). Structural investigation of pathogenic RFC1 AAGGG pentanucleotide repeats reveals a role of G-quadruplex in dysregulated gene expression in CANVAS. Nucleic Acids Research, 52(5), 2698-2710.

Wan, L., He, A., Li, J., Guo, P.,* & Han, D.* (2024). High-Resolution NMR Structures of Intrastrand Hairpins Formed by CTG Trinucleotide Repeats. ACS Chemical Neuroscience, 15(4), 868-876.

Tian, Y., Miao, Y., Guo, P., Wang, J.,* & Han, D.* (2024). Insulin‐like Growth Factor 2‐Tagged Aptamer Chimeras (ITACs) Modular Assembly for Targeted and Efficient Degradation of Two Membrane Proteins. Angewandte Chemie International Edition, 63(5), e202316089.

Deng, L., Guo, P., Han, D.*, & Tan, W. (2023). Sensing miRNAs for disease diagnostics. Analysis & Sensing, 3(4), e202200083.

Xu, R., Tang, Q., Ying, Y., & Han, D.* (2023). Surface Functionalization of Extracellular Vesicles with Nucleic Acids towards Biomedical Applications. Current Topics in Medicinal Chemistry, 23(14), 1307-1318.

Qi, L., Tian, Y., Li, N., Mao, M., Fang, X., & Han, D.* (2023). Engineering circular aptamer assemblies with tunable selectivity to cell membrane antigens in vitro and in vivo. ACS Applied Materials & Interfaces, 15(10), 12822-12830.

Zheng, T., Tang, Q., Wan, L., Zhao, Y., Xu, R., Xu, X., ... & Han, D.* (2023). Controlled Self-Assembly of the Catalytic Core of Hydrolases Using DNA Scaffolds. Nano Letters, 23(6), 2081-2086.

Lv, C., Li, Y., Zhang, M., Cheng, Y., Han, D.*, & Tan, W. (2023). Sequential control of cellular interactions using dynamic DNA displacement. Nano Letters, 23(4), 1167-1174.

Liu, J., Zhang, C., Song, J., Zhang, Q., Zhang, R., Zhang, M., Han, D.* & Tan, W. (2023). Unlocking genetic profiles with a programmable DNA‐powered decoding circuit. Advanced Science, 10(20), 2206343.

Zhang, M., & Han, D. (2023). Concept, Development and Applications of DNA Computation. Fundamental Research.

Yin, Y., Xie, W., Xiong, M., Gao, Y., Liu, Q., Han, D., ... & Zhang, X. B. (2023). FINDER: A Fluidly Confined CRISPR‐Based DNA Reporter on Living Cell Membranes for Rapid and Sensitive Cancer Cell Identification. Angewandte Chemie International Edition, 62(44), e202309837.

Li, Y., Liu, X., Yu, L., Huang, X., Wang, X., Han, D.*, ... & Liu, Z. (2023). Covalent LYTAC enabled by DNA aptamers for immune checkpoint degradation therapy. Journal of the American Chemical Society, 145(45), 24506-24521.

Yang, C., Zhao, H., Sun, Y., Wang, C., Geng, X., Wang, R., Han, D.* ... & Tan, W. (2022). Programmable manipulation of oligonucleotide–albumin interaction for elongated circulation time. Nucleic acids research, 50(6), 3083-3095.

Zhang, C., Zheng, T., Ma, Q., Yang, L., Zhang, M., Wang, J., ... & Han, D.* (2022). Logical Analysis of Multiple Single‐Nucleotide‐Polymorphisms with Programmable DNA Molecular Computation for Clinical Diagnostics. Angewandte Chemie International Edition, 61(15), e202117658.

Yi, J., Wan, L., Liu, Y., Lam, S. L., Chan, H. Y. E., Han, D.*, & Guo, P. (2022). NMR solution structures of d (GGCCTG) n repeats associated with spinocerebellar ataxia type 36. International Journal of Biological Macromolecules, 201, 607-615.

Ying, Y., Tang, Q., Han, D.*, & Mou, S. (2022). Nucleic acid nanotechnology for diagnostics and therapeutics in acute kidney injury. International Journal of Molecular Sciences, 23(6), 3093.

Vittala, S. K., Zhao, Y., & Han, D.* (2022). Programmed Assembly of DNA Templates by Silver Nanowires. ChemPlusChem, 87(1), e202100478.

Guo, P., & Han, D.* (2022). Targeting pathogenic DNA and RNA repeats: A conceptual therapeutic way for repeat expansion diseases. Chemistry–A European Journal, 28(54), e202201749.

Chao, D., Xu, X., Miao, Y., Yang, L., Gao, Q., Xu, R., ... & Han, D.* (2022). Covalent stabilization of DNA nanostructures on cell membranes for efficient surface receptor-mediated labeling and function regulations. Science China Chemistry, 65(11), 2327-2334.

Ma, Q., Zhang, M., Zhang, C., Teng, X., Yang, L., Tian, Y., Han, D.*, ... & Tan, W. (2022). An automated DNA computing platform for rapid etiological diagnostics. Science Advances, 8(47), eade0453.

Zhang, C., Zheng, T., Fan, H., Zhang, T., & Han, D.* (2021). Aligner-mediated cleavage-based isothermal amplification for SARS-CoV-2 RNA detection. ACS Applied Bio Materials, 4(5), 3805-3810.

Zhang, C., Zheng, T., Wang, H., Chen, W., Huang, X., Liang, J., Han, D.*... & Tan, W. (2021). Rapid one-pot detection of SARS-CoV-2 based on a lateral flow assay in clinical samples. Analytical chemistry, 93(7), 3325-3330.

Xu, X., & Han, D.* (2021). DNA‐Guided Programmable Protein Assemblies for Biomedical Applications. ChemPlusChem, 86(2), 284-290.

Zhao, Y., Zuo, X., Li, Q., Chen, F., Chen, Y. R., Deng, J., Han, D, ... & Fan, C. (2021). Nucleic acids analysis. Science China Chemistry, 64, 171-203.

Li, Y., Deng, J., Han, Z., Liu, C., Tian, F., Xu, R., Han, D.*, ... & Sun, J. (2021). Molecular identification of tumor-derived extracellular vesicles using thermophoresis-mediated DNA computation. Journal of the American Chemical Society, 143(3), 1290-1295.

Miao, Y., Gao, Q., Mao, M., Zhang, C., Yang, L., Yang, Y., & Han, D.* (2021). Bispecific aptamer chimeras enable targeted protein degradation on cell membranes. Angewandte Chemie, 133(20), 11367-11371.

Tang, Q., & Han, D.* (2021). Obtaining Precise Molecular Information via DNA Nanotechnology. Membranes, 11(9), 683.

Ma, Q., Zhang, C., Zhang, M., Han, D.*, & Tan, W. (2021). DNA computing: Principle, construction, and applications in intelligent diagnostics. Small Structures, 2(11), 2100051.

Zhao, Y., Zhang, C., Yang, L., Xu, X., Xu, R., Ma, Q., ... & Han, D.* (2021). Programmable and site‐specific patterning on DNA origami templates with heterogeneous condensation of silver and silica. Small, 17(47), 2103877.

Zhang, C., Zhao, Y., Xu, X., Xu, R., Li, H., Teng, X., ... & Han, D.* (2020). Cancer diagnosis with DNA molecular computation. Nature nanotechnology, 15(8), 709-715.

Yang, L., Miao, Y., & Han, D.* (2020). DNA nanotechnology on live cell membranes. Chemical Research in Chinese Universities, 36(2), 203-210.

Sun, Y., Gao, F., Yang, C., Li, Y., Jin, C., Xie, S., Ding, D., Han, D., & Tan, W. (2020). Construction of bispecific aptamer–drug conjugate by a hybrid chemical and biological approach. Bioconjugate chemistry, 31(5), 1289-1294.

Vittala, S. K., & Han, D.* (2020). DNA-guided assemblies toward nanoelectronic applications. ACS Applied Bio Materials, 3(5), 2702-2722.

Lyu, Y., Peng, R., Liu, H., Kuai, H., Mo, L., Han, D., ... & Tan, W. (2020). Protocells programmed through artificial reaction networks. Chemical Science, 11(3), 631-642.

Lv, C., Gu, X., Li, H., Zhao, Y., Yang, D., Yu, W., Han, D.*, Li, J., & Tan, W. (2020). Molecular transport through a biomimetic DNA channel on live cell membranes. ACS nano, 14(11), 14616-14626.

Yang, L., Zhao, Y., Xu, X., Xu, K., Zhang, M., Huang, K., ... & Han, D.* (2020). An intelligent DNA nanorobot for autonomous anticoagulation. Angewandte Chemie, 132(40), 17850-17857.

Gao, Q., Zhao, Y., Xu, K., Zhang, C., Ma, Q., Qi, L., ... & Han, D.* (2020). Highly specific, single‐step cancer cell isolation with multi‐aptamer‐mediated proximity ligation on live cell membranes. Angewandte Chemie International Edition, 59(52), 23564-23568.

Lv, C., Yang, C., Ding, D., Sun, Y., Wang, R., Han, D.*, & Tan, W. (2019). Endocytic pathways and intracellular transport of aptamer-drug conjugates in live cells monitored by single-particle tracking. Analytical chemistry, 91(21), 13818-13823.

Han, D., Li, J., & Tan, W. (2019). CRISPR propels a smart hydrogel. Science, 365(6455), 754-755.

Chang, X., Zhang, C., Lv, C., Sun, Y., Zhang, M., Zhao, Y., Yang, L., Han, D.* & Tan, W. (2019). Construction of a multiple-aptamer-based DNA logic device on live cell membranes via associative toehold activation for accurate cancer cell identification. Journal of the American Chemical Society, 141(32), 12738-12743.

Ding, D., Han, D., Li, J., & Tan, W. (2019). Improving early detection of cancers by profiling extracellular vesicles. Expert Review of Proteomics, 16(7), 545-547.

Yang, L., Meng, L., Song, J., Xiao, Y., Wang, R., Kang, H., & Han, D.* (2019). Dynamic colloidal nanoparticle assembly triggered by aptamer–receptor interactions on live cell membranes. Chemical Science, 10(31), 7466-7471.

Lyu, Y., Wu, C., Heinke, C., Han, D., Cai, R., Teng, I. T., ... & Tan, W. (2018). Constructing smart protocells with built-in DNA computational core to eliminate exogenous challenge. Journal of the American Chemical Society, 140(22), 6912-6920.

Wu, W., Zhang, T., Han, D., Fan, H., Zhu, G., Ding, X., ... & Tan, W. (2018). Aligner-mediated cleavage of nucleic acids and its application to isothermal exponential amplification. Chemical Science, 9(11), 3050-3055.

Zhang, R., Gao, S., Wang, Z., Han, D., Liu, L., Ma, Q., ... & Chen, X. (2017). Multifunctional molecular beacon micelles for intracellular mRNA imaging and synergistic therapy in multidrug‐resistant cancer cells. Advanced functional materials, 27(31), 1701027.

You, M., Lyu, Y., Han, D., Qiu, L., Liu, Q., Chen, T., ... & Tan, W. (2017). DNA probes for monitoring dynamic and transient molecular encounters on live cell membranes. Nature nanotechnology, 12(5), 453-459.

Han, D., Wu, C., You, M., Zhang, T., Wan, S., Chen, T., ... & Tan, W. (2015). A cascade reaction network mimicking the basic functional steps of adaptive immune response. Nature chemistry, 7(10), 835-841.

​​​​​​​Qiu, L., Chen, T., Öçsoy, I., Yasun, E., Wu, C., Zhu, G., You, M., Han D., Jiang J., Yu R., Tan, W. (2015). A cell-targeted, size-photocontrollable, nuclear-uptake nanodrug delivery system for drug-resistant cancer therapy. Nano letters, 15(1), 457-463.

Han, D., Wu, C., & Tan, W. (2015). Molecular Engineering to Enhance Aptamer Functionality. Aptamers Selected by Cell-SELEX for Theranostics, 89-109.

Zhu, G., Cansiz, S., You, M., Qiu, L., Han, D., Zhang, L., ... & Tan, W. (2015). Nuclease-resistant synthetic drug-DNA adducts: programmable drug-DNA conjugation for targeted anticancer drug delivery. NPG Asia Materials, 7(3), e169-e169.