核酸分子工程与纳米技术实验室

核酸分子工程与纳米技术实验室

  • 44. Cheng Lv#, Xiyao Gu#, Haowen Li, Yumeng Zhao, Donglei Yang, Weifeng Yu*, Da Han*, Juan Li, Weihong Tan*. Molecular Transport through a Biomimetic DNA Channel on Live Cell Membranes. ACS Nano, 2020, Accepted. doi:10.1021/acsnano.0c03105

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

    43. Yongxi Zhao#, Xiaolei Zuo#, Qian Li#, ..., Da Han, ... Chao Zhang, ...Chaoyong Yang*, Xiao-Bing Zhang*, Huanghao Yang*, Weihong Tan*, Chunhai Fan*. Nucleic Acid Analysis. SCIENCE CHINA Chemistry, 2020, Accetpted. (Full text) 

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

    42. Qianqian Gao#, Yumeng Zhao#, Kangli Xu, Chao Zhang, Qian Ma, Liqing Qi, Dandan Chao, Tingting Zheng, Linlin Yang, Yanyan Miao, Da Han*. Highly Specific, Single-step Cancer Cell Isolation With Multi-Aptamer-Mediated Proximity Ligation on Live Cell Membranes. Angew. Chem. Int. Ed. 2020. Accepted. doi: 10.1002/anie.202011198

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

    41. Linlin Yang, Yumeng Zhao, Xuemei Xu, Kangli Xu, Mingzhi Zhang, Kui Huang, Huaizhi Kang*, Hsiao-chu Lin, Yang Yang*, Da Han*. An intelligent DNA nanorobot for autonomous anticoagulation. Angew. Chem. Int. Ed.. 2020, 59(40): 17697-17704. (Full text) doi:10.1002/anie.202007962

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

    40. Chao Zhang, Yumeng Zhao, Xuemei Xu, Rui Xu, Haowen Li, Xiaoyan Teng, Yuzhen Du, Yanyan Miao, Hsiao-chu Lin, Da Han*. Cancer Diagnosis with DNA Molecular Computation. Nature Nanotechnology, 2020, 15: 709-715. (Full text(Nat Nanotech News)

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

    39. Sandeepa Kulala Vittala, Da Han*. DNA-Guided Assemblies toward Nanoelectronic Applications. ACS Applied Bio Materials, 2020, 3, 5: 2702-2722.  (Full text)

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

    38. Linlin Yang, Yanyan Miao, Da Han*. DNA Nanotechnology on Live Cell Membranes. Chemical Research in Chinese University, 2020, 36(2): 203-210. (Full text)

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

    37. Yifan Lyu, Ruizi Peneg, Hui Liu, Hailan Kuai, Liuting Mo, Da Han, Juan Li*, Weihong Tan*. Protocells Programmed through Artificial Reaction Networks. Chemical Science, 2020, 11: 631-642. (Full text)

     
  • 36. Cheng Lv, Cai Yang, Ding Ding, Yang Sun, Ruowen Wang, Da Han*, Weihong Tan*. Endocytic Pathways and Intracellular Transport of Aptamer-drug Conjugates in Live Cells Monitored by Single-particle Tracking. Analytical Chemistry, 2019, 91(21): 13818-13823. (Full text)

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

    35. Da Han, Juan Li, Weihong Tan. CRIPSR Propels a Smart Hydrogel. Science, 2019, 365(6455): 754-755. (Full text)

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

    34. Xu Chang, Chao Zhang, Cheng Lv, Yang Sun, Mingzhi Zhang, Yumeng Zhao, Linlin Yang, Da Han*,Weihong Tan*. Construction of a Multitple-aptamer-based DNA Logic Device on Live Cell Membranes via Associative Toehold Activation for Accurate Cancer Cell Identification. Journal of the American Chemistry Society, 2019, 141(32): 12738-12743. (Full text)

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

    33. Linlin Yang, Lingyan Meng, Jiaying Song, Yue Xiao, Ruowen Wang, Huaizhi Kang* and Da Han *. Dynamic Colloidal Nanoparticle Assembly Triggered by Aptamer-receptor Interactions on Live Cell Membranes. Chemical Science, 2019, 10, 7466-7471. (Full text)

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

    32. Ding Ding, Da Han, Juan Li and Weihong Tan. Improving Early Detection of Cancers by Profiling Extracellular Vesicles, Expert Review of Proteomics, 2019, 16, 545-547. (Full text)

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

    31. Yumeng Zhao and Da Han*. Nucleic Acid Based Intelligent Systems and Their Biomedical Applications. SCIENTIA SINICA Chimica (中国科学:化学), 2019, 62,1-7. (Full text)

     

  • 30. Yifan Lyu, Cuichen Wu, Charles Heinke, Da Han* (Co-corresponding author), Ren Cai, I-Ting Teng, Yuan Liu, Hui Liu, Xiao-Bing Zhang, Qiaoling Liu, Weihong Tan*. Constructing Smart Protocells with Built-in DNA Computational Core to Eliminate Exogenous Challenge. Journal of the American Chemical Society, 2018, 140 (22), 6912–6920. (Full text)

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

    29. Wanghua Wu, Tao Zhang, Da Han, Hongliang Fan, Guizhi Zhu, Xiong Ding, Cuichen Wu, Mingxu You, Liping Qiu, Juan Li, Liqin Zhang, Xiang Lian, Rong Hu, Ying Mu, Jianguang Zhou, Weihong Tan. Aligner-Mediated Cleavage of Nucleic Acids and Its Application to Isothermal Exponential Amplification. Chemical science, 2018, 9, 3050-3055. (Full text)

     

     

  • 28. Ruili Zhang, Shi Gao, Zhongliang Wang, Da Han, Lin Liu, Qingjie Ma, Weihong Tan, Jie Tian, Xiaoyuan Chen. Multifunctional Molecular Beacon Micelles for Intracellular mRNA Imaging and Synergistic Therapy in Multidrug Resistant Cancer Cells. Advanced functional materials, 2017, 27, 170127. (Full text)

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

    27. Mingxu You, Yifan Lv, Da Han (Co-first author), Liping Qiu, Qiaoling Liu, Tao Chen, Cuicheng Wu, Lu Peng, Liqin Zhang, Gang Bao and Weihong Tan. DNA Probes for monitoring dynamic and transient molecular encounters on live cell membranes. Nature Nanotechnology, 2017, 5, 453-459. (Full text)

     

  • 26. Da Han and Weihong Tan. Molecular Engineering to Enhance Aptamer Functionality. In: Aptamers Selected by Cell SELEX for Theranostics, Springer, 2015. Book Chapters. (Full text)

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

    25. Da Han, Cuichen Wu, Mingxu You, Tao Zhang, Shuo Wan, Tao Chen, Liping Qiu, Zheng Zheng, Hao Liang, and Weihong Tan. A Cascade Reaction Network Mimicking the Basic Functional Steps of Acquired Immune Response. Nature Chemistry, 2015, 7(10),835-841. (Full text)

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

    24. Guizhi Zhu, Sena Cansiz, Mingxu You, Liping Qiu, Da Han, Liqin Zhang, Lei Mei, and Ting Fu and Weihong Tan. Nuclease-resistant Synthetic Drug-DNA Adducts: Programmable Drug-DNA Conjugation for Targeted Anticancer Drug Delivery. NPG Aisa Materials, 2015, 7, e169. (Full text)

     

     

  • 23. Da Han, Huaizhi Kang, Tao Zhang, Cuichen Wu, Cuisong Zhou, Mingxu You, Zhuo Chen, Xiaobing Zhang, Weihong Tan. Nucleic Acid Based Logical Systems (Concept paper), Chemistry-A European Journal, 2014,20, 5866-5873. (Full text)

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

    22. Liping Qiu, Tao Chen, Ismail Öçsoy, Emir Yasun, Cuichen Wu, Guizhi Zhu, Mingxu You, Da Han, Jianhui Jiang, Ruqin Yu, Weihong Tan. A Cell-Targeted, Size-Photocontrollable, Nuclear-Uptake Nanodrug Delivery System for Drug-Resistant Cancer Therapy. Nano letter, 2014, 15, 457-463. (Full text)

     

     

     

     

     

     

  • 21. Cuichen Wu, Da Han (Co-first author), Tao Chen, Lu Peng, Guizhi Zhu, Mingxu You, Liping Qiu, Kwame Sefah, Xiao-Bing Zhang, Weihong Tan. Building a Multifunctional Aptamer-Based DNA Nanoassembly for Targeted Cancer Therapy. Journal of the American Chemical Society, 2013, 135, 18644-18650. (Full text)

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

    20. Da Han, Guizhi Zhu, Cuichen Wu, Zhi Zhu, Tao Chen, Xiaobing Zhang and Weihong Tan. Engineering a Cell-Surface Aptamer Circuit for Targeted and Amplified Photodynamic Cancer Therapy. ACS Nano, 2013,7,2312-2319. (Full text)

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

    19. Fujian Huang, Mingxu You, Da Han, Xiangling Xiong, Haojun Liang, and Weihong Tan. DNA Branch Migration Reactions Through Photocontrollable Toehold Formation. Journal of the American Chemical Society, 2013,135, 21, 7967-7973. (Full text)

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

    18. Liping Qiu#, Cuichen Wu, Mingxu You, Da Han, Tao Chen, Guizhi Zhu, Jianhui Jiang, Ruqin YuQiu and Weihong Tan.A Targeted, Self-Delivered, and Photocontrolled Molecular Beacon for mRNA Detection in Living Cells. Journal of the American Chemical Society, 2013, 135, 12952-12955. (Full text)

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

    17. Cuichen Wu, Tao Chen, Da Han, Mingxu You, Lu Peng, Sena Cansiz, Guizhi Zhu, Chunmei Li, Xiangling Xiong, Elizabeth Jimenez, Chaoyong James Yang, Weihong Tan. Engineering of Switchable Aptamer Micelle Flares for Molecular Imaging in Living Cells. ACS Nano,2013,7,5724-5731. (Full text)

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

    16. Lu Peng, Cuichen Wu, Mingxu You, Da Han, Yan Chen, Ting Fu, Mao Ye, Weihong Tan. Engineering and Applications of DNA-Grafted Polymer Materials. Chemical Science, 2013, 5, 1928-1938. (Full text)

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

    15. Tao Chen, Cuichen Wu, Elizabeth Jimenez, Zhi Zhu, Joshua Dajac, Mingxu You, Da Han, Xiaobing Zhang and Weihong Tan. DNA Micelle Flares for Intracellular mRNA Imaging and Gene Therapy. Angewandte Chemie,International Edition, 2013, 52, 2012-2016. (Full text)

     

     

     

  • 14. Da Han, Zhi Zhu, Cuichen Wu, Lu Peng, Leiji Zhou, Basri Gulbakan, Guizhi Zhu, Kathryn Williams, Weihong Tan. A Logical Molecular Circuit for Programmable and Autonomous Regulation of Protein Activity Using DNA Aptamer–Protein Interactions. Journal of the American Chemical Society, 2012, 134, 20797-20804. (C&EN-NEWS, http://cen.acs.org/articles/90/web/2012/12/DNA-Circuits-Control-Clotting-Protein.html ). (Full text)

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

    13. Mohammed I. Shukoor, Meghan O’Donoghue, Da Han, Tahir Bayrac, Ismail Ocsoy, Zhi Zhu and Weihong Tan. Aptamer-Nanoparticle Assembly for Logic-Based Detection. ACS Applied Materials & Interfaces, 2012, 4, 3007-3011. (Full text)

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

    12. Lu Peng, Mingxu You, Quan Yuan, Cuichen Wu, Da Han, Yan Chen, Zhihua Zhong, Jiangeng Xue and Weihong Tan. Macroscopic Volume Change of Dynamic Hydrogels Induced by Reversible DNA Hybridization. Journal of the American Chemical Society, 2012, 134, 12302-12307. (Full text)

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

    11. Cuichen Wu, Lu Peng, Mingxu You, Da Han, Tao Chen, Kathryn Williams, Chaoyong Yang and Weihong Tan. Engineering Molecular Beacons for Intracellular Imaging. International journal of molecular imaging, 2012,501579. (Full text)

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

    10. Wei Zhang, Bo Zhang, Yulong Zhang, Da Han, Yongliang Zhou. Trapping Yeast Cells on PDMS Micropillar Array. Advanced Material Research, 2012, 476-478. (Full text)

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

    9. Lu Peng, Zhi Zhu, Yan Chen, Da Han, and Weihong Tan. An exonuclease III and graphene oxide-aided assay for DNA detection. Biosensors and Bioelectronics, 2012, 35, 475-478. (Full text)

  • 8. Da Han, Chaoyong Yang and Weihong Tan. Functional materials for signal amplification of molecular beacons. In: Molecular Beacons, Springer, Heidelberg, 2011. Book Chapters. (Full text)

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

    7. Da Han, Jin Huang, Zhi Zhu, Quan Yuan, Mingxu You, Yan Chen and Weihong Tan. Molecular Engineering of Photoresponsive Three-Dimensional DNA Nnanostructures. Chemical Communications, 2011, 47, 4670-4672. (Full text)

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

    6. Pu Ying, Zhi Zhu, Da Han (Co-first author), Huixia Liu, Jun Liu, Jie Xia, Kejing Zhang and Weihong Tan. Insulin-Binding Aptamer-Conjugated Graphene Oxide for Insulin Detection. Analyst, 2011,136, 4138-4140. (Full text)

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

    5. Kelong Wang, Mingxu You, Yan Chen, Da Han, Zhi Zhu, Jin Huang, Kathryn Williams, Chaoyong James Yang and Weihong Tan. Self-Assembly of a Bifunctional DNA Carrier for Drug Delivery. Angewandte Chemie, International Edition, 2011, 50, 6098-6101. (Full text)

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

    4. Mingxu You, Yan Chen, Lu Peng, Da Han, Bincheng Yin, Bangce Ye and Weihong Tan. Engineering DNA Aptamers for Novel Analytical and Biomedical Applications. Chemical Science, 2011, 2, 1003-1010.   (Full text)

  • 3. Yunfei Zhang, Yan Chen, Da Han, Ismail Ösçoy and Weihong Tan. Aptamers Selected by Cell-SELEX for Application in Cancer Studies. Bioanalyst, 2010, 2, 907-918. (Full text)

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

    2. Mingxu You, Zhi Zhu, Haipeng Liu, Basri Gulbakan, Da Han, Ruowen Wang, Kathryn Williams and Weihong Tan. Pyrene-Assisted Efficient Photolysis of Disulfide Bonds in DNA-Based Molecular Engineering. ACS Applied Materials & Interfaces, 2010, 2, 3601-3605. (Full text)

     

     

     

  • 1. Yuan Li, Da Han, Shumin Han, Xilin Zhu, Lin Hu, Zhong Zhang, Yuwen Liu. Effect of Rare Earth Elements on Electrochemical Properties of La-Mg-Ni-Based Hydrogen Storage Alloys. International Journal of Hydrogen Energy, 2009, 34, 1399-1404. (Full text)